Endocrine Abstracts

Introduction: Vitamin D deficiency (25OHD) is common in women with polycystic ovary syndrome (PCOS). 67–85% of female patients with PCOS have low concentration level of 25OHD (<20 ng/ml). It is believed that low concentration levels of 25OHD may exacerbate the symptoms of PCOS.Aim: The aim of the study was to evaluate the concentration of 25OHD in women diagnosed with PCOS and the analysis of the relationship between 25OHD concentration and such...

Objective: Evaluation of aftercare, medical therapy and remission rate in Cushing’s disease (CD) and acromegaly (AC).Methods: Of 58 CD and 83 AC patients operated over 10 years were carefully evaluated. The patients received a disease-related questionnaire and were invited for a follow-up at the outpatient clinic of the Department of Neurosurgery. 33 CD and 52 AC patients returned the questionnaire, 25 CD and 37 AC patients participated personally. ...

Objective: Cushing’s disease (CD) and acromegaly (AC) are associated with psychological and psychiatric problems. Both pathologies cause a severe impairment in quality of life (QoL) that can persist even if biochemical remission and cure are achieved. The aim of the study was to investigate the influence of the current disease status (remission vs. no remission) on neurocognitive function and QoL in treated CD and AC patients. The second objective was to determine predict...

Objective: The aim of the study was to analyze the time-to-diagnosis interval in patients with Cushing’s disease (CD) and acromegaly (AC), to assess factors that promote early disease detection and to investigate the medical fields diagnosing the pathologies.Design: Case-record retrospective study.Patients: CD and 52 AC patients operated between June 1998 and December 2007.Measurements: All patients rece...

Ovarian function in mammals is regulated by gonadotropins and by sympathetic nervous system. Norepinephrine (NE) is one of the major neurotransmitters present in the fibres innervating the gonad and regulates follicular development and ovarian steroids release. Surgical section of the sympathetic fibres partially decreased the release of NE as compared with non-denervated rats. The remnant release capability supposes the existence of an intraovarian compartment able to incorpo...

We report pregnancies obtained after stimulation by gonadotropins in 3 patients with IHH caused by homozygous or compound heterozygous mutations of GnRH receptor: (R139H/R262Q, R139C/ R139C, R139H/ Phe 308 del.);Gonadotropin response to GnRH was observed in the first patient. All the patients were stimulated with gonadotrophins according to the protocole step up with the initial dose of 150IU FSH and 75 IU LH a day. The luteal phase was suported by hCG a...

Background: ACTH concentrations remain typically elevated in patients with Addison’s disease. We present a case of an extremely potent oral contraceptive pill (OCP) induced increase in total cortisol resulting in inhibition of ACTH secretion that was normalized on OCP withdrawal.Case Presentation: A 20-year old female was diagnosed with Addison’s disease [cortisol 1.59 µg/dl, ACTH>500 pg/ml (0-65)] and...

Introduction: Papillary Thyroid Carcinoma (PTC) exhibits activation of MAPK (Mitogen-activated protein kinases) pathway, leading to uncontrolled cellular division and growth. Concomitantly, thyroid tumors exhibit aberrant expression of numerous microRNAs, which are non-coding RNAs that inhibit expression of protein-coding genes. Employing next-generation sequencing (NGS), we revealed comprehensive miRNA profiles of normal thyroid and PTC, and identified putative novel microRNA...

Background: Amiodarone-induced thyrotoxicosis is sometimes extremely difficult to treat necessitating emergency thyroidectomy with perioperative risks including possible thyroid storm. We obtained near normalization of free T3 (FT3) by pulse Methylprednisolone prior to thyroidectomy for drug-resistant Amiodarone-induced thyrotoxicosis.Case Description: A 56 year old man (BMI 29.7 kg/m2), with history atrial flutter/fibrillation, episodes of fa...

Laparoscopic surgery of adrenal tumours is widely used because of its high effectiveness, patients safety and relatively low cost. Current indications to adrenalectomy of oncological and endocrinological origin are highly accepted. However there is still lack of perfect clinical tool identifying malignant lesions. In everyday practice clinicians rely on low specific features, especially considering larger nonsecretory lesions to surgery.To show the lands...